1. Nakamaru R, Nakagami H, Hayashi H, Sun J, Tenma A, Yamamoto K, Shimamura M, Morishita R, Rakugi H. A novel angiotensin Ⅱ peptide vaccine without an adjuvant in mice. J Hypertens. (Accepted)

  2. Yoshida S, Nakagami H, Hayashi H, Ikeda Y, Sun J, Tenma A, Tomioka H, Kawano T, Shimamura M, Morishita R, Rakugi H. The CD153 vaccine is a senotherapeutic option for preventing the accumulation of senescent T cells in mice. Nat. Commun. 2020 May 18;11(1):2482.


  1. Hironori Nakagami, Ryuichi Morishita, Shuko Takeda, Munehisa Shimamura, Tomohiro Kawano, Kouji Wakayama, Tatsuhiko Azegami, Hiroshi Itoh, Jiao Sun, Hiroki Hayashi, Kunihiko Yamashita, Hideki Tomioka, Akiko Tenma, Makoto Sakaguchi. Therapeutic Vaccines as Novel Immunotherapy. Springer. 2019 Dec.

  2. Tenma A,Nakagami H,Tomioka H,Sakaguchi M,Ide R,Koriyama H,Hayashi H,Shimamura M, Rakugi H,Morishita.,AJP001, a novel helper T-cell epitope, induces a humoral immune response with activation of innate immunity when included in a peptide vaccine. FASEB Bioadv. 2019 Nov 22;1(12):760-772.

  3. Nakagami H, Sugimoto K, Ishikawa T, Koshizaka M, Fujimoto T, Kiyohara E, Hayashi M, Nakagawa Y, Ando H, Terabe Y, Takami Y, Yamamoto K, Takeya Y, Takemoto M, Ebihara T, Nakamura A, Nishikawa M, Yao XJ, Hanaoka H, Yokote K, Rakugi H. Investigator-initiated clinical study of a functional peptide, SR-0379, for limb ulcers of patients with Werner syndrome as a pilot study. Geriatr Gerontol Int. 2019


  1. Nakagami H, Sugimoto K, Ishikawa T, Fujimoto T, Yamaoka T, Hayashi M, Kiyohara E, Ando H, Terabe Y, Takami Y, Yamamoto K, Takeya Y, Takemoto M, Koshizaka M, Ebihara T, Nakamura A, Nishikawa M, Yao XJ, Hanaoka H, Katayama I, Yokote K, Rakugi H. Physician-initiated clinical study of limb ulcers treated with a functional peptide, SR-0379: from discovery to a randomized, double-blind, placebo-controlled trial. NPJ Aging Mech Dis. 2018;4:2


  1. Tenma A, Development of antibody-inducing peptide aiming at practical application of functional peptides, 2017.2.22, Tokyo

  2. Nakagami H, Yamaoka T, Hayashi M, Tanemura A, Takeya Y, Kurinami H, Sugimoto K, Nakamura A, Tomono K, Tamai K, Katayama I, Rakugi H, Kaneda Y. Physician-initiated first-in-human clinical study using a novel angiogenic peptide, AG30/5C, for patients with severe limb ulcers. Geriatr Gerontol Int. 2017 May

  3. Peptide drug screening / stabilization / formulation technology, Technical information Institute Co., Ltd.


  1. Tenma A, Tomioka H, Nakagami H and Morishita R, Development of peptides that have both wound healing and antimicrobial activities, BIO INDUSTRY, CMC Publishing Co., Ltd. Vol.32, No.3, 49-56, 2015.3

  2. Tomioka H, Development of antimicrobial peptide as a wound healing treatment, Endotoxin / Innate immunity research, Igakutosho Shuppan, Vol.18, 13-18, 2015.9

  3. Tenma A, Development of functional peptide material that has both anti-aging effect and antibacterial effect, CMC Publishing Co., Ltd., Latest Developments in Functional Peptides


  1. Tenma A, Development of anti-aging peptides using platform technology, 14th Scientific Meeting of the Japanese Society of Anti-Aging Medicine, 2014.6.6, Osaka

  2. Pang Z, Nakagami H, Osako M, Koriyama H, Nakagami F, Tomioka H, Shimamura M, Kurinami H, Takami Y, Morishita R, Rakugi H. Therapeutic vaccine against DPP4 improves glucose metabolism in mice. Proceedings of the National Academy of Sciences USA 2014;111:E1256-1263.

  3. Tomioka H, Nakagami H, Tenma A, Saito Y, Kaga T, Kanamori T, Tamura N, Tomono K, Kaneda Y, Morishita R. Novel anti-microbial peptide SR-0379 accelerates wound healing via the PI3 kinase/akt/mTOR pathway. PLoS One 2014;9:e92597.


  1. Nakagami H, Nishikawa T, Tamura N, Maeda A, Hibino H, Mochizuki M, Shimosato T, Moriya T, Morishita R, Tamai K, Tomono K, Kaneda Y. Modification of a Novel Angiogenic Peptide, AG30, for the Development of Novel Therapeutic Agents. J Cell Mel Med 2012 Jul;16(7):1629-1639

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